HA5 TM Rejuvenating Hydrator

Provides immediate smoothing in the appearance of fine lines and wrinkles, and supports the skin's natural ability to replenish its own hyaluronic acid for overall skin health.

Appropriate for all skin types.

56.7 g

Patient Feedback

Baseline vs. 15 Minutes, Male, Age 63

Baseline vs. 8 Weeks, Female, Age 50

Unretouched photos taken with parallel-polarized lighting. Individual results may vary. For 15-Minute results, product was left on subject’s face. For 8-Week resluts, no product on subject's face. Data on file at SkinMedica®.


of subjects

agreed that immediately after applying HA5 TM it made their skin feel smooth and soft*.


of subjects

agreed that after 8 weeks of twice-daily use, HA5 TM made their skin feel "more refreshed” and “moisturized"*.


of subjects

agreed that HA5 TM was convenient and works well with other products*.

*Narurkar VA, Fabi SG, Bucay VW, et al. A New Approach in Topical Hyaluronic Acid; Going Beyond Instant Benefits to Restore Epidermal HA Homeostasis. J Drug Dermatol. 2016:15(1 Suppl2);s24-s37.

Key Benefits of HA5 TM

HA5 TM delivers both immediate and long-term benefits

Instantly smoothes the appearance of fine lines and wrinkles

Immediate hydration

Improves the appearance of skin texture and roughness

Exponentially Smooth

Introducing a new chapter in skin hydration. HA5 TM supports the skin’s ability to replenish its own HA for overall skin health. HA5 TM has a proprietary mix of five HA forms that smooth the skin, thereby decreasing the appearance of fine lines and wrinkles. The 5 HA's work synergistically to provide immediate smoothing and continuous hydration throughout the day.

What’s Inside

Key Ingredients

VITISENSCE® Technology:

A SkinMedica® exclusive technology that harnesses potent antioxidants found in Vitis Flower Stem Cell Extract, Peptide Complex to support rejuvenation and hydration, and Polysaccharides from French Polynesia for healthy-looking skin - all working to support skin's ability to replenish its own hyaluronic acid for overall skin health.

Specialty Ingredients

A proprietary mix of five types of HA that smooth the skin, thereby decreasing the appearance of fine lines and wrinkles.


Time Release HA:

A SkinMedica® proprietary ingredient for sustained release of HA

Sodium Hyaluronate:

For immediate hydration

Uncross-linked HA:

For smoothness and hydration

Nano HA:

Soothes skin

Cross-Linked HA:

Provides long-lasting hydration for up to 8 hours

When to Apply

Apply twice daily—in the morning and at night—after cleansing, toning, and treating your skin. Apply before you moisturize and apply SPF (sun protection).

Where to Apply

Apply to face, neck and décolleté, or any area where fine lines and wrinkles primarily exist.

How to Apply

Because HA5 TM is a "water-loving" substance, wet your fingertips prior to applying HA5 TM to your skin.

Additional Information

What's the difference between a moisturizer and a hydrator?

A moisturizer is a cosmetic cream or lotion made with humectants or occlusive or a combination of both that prevent skin dryness. A hydrator is a cosmetic treatment product that promotes epidermal health by supporting the skin’s natural ability to replenish HA.

Is HA5 TM Rejuvenating Hydrator oil free, fragrance free and non-comedogenic?

Yes, HA5 TM is oil free and fragrance free, and is appropriate for all skin types. HA5 TM is considered non-comedogenic.

Is it safe to use for a person with a milk allergy?

No. HA5 TM contains whey protein that is derived from milk powder. Therefore, a person with a history of milk or whey protein allergy that triggers an immune response should not use this product because they may experience an allergic reaction.

How should HA5 TM Rejuvenating Hydrator be used within a regimen?

HA5 TM Rejuvenating Hydrator can be used with any SkinMedica® product or regimen to support hydration. It should be applied immediately before moisturizer in a normal regimen.

Making Comparisons

HA5 TM vs. TNS Essential Serum®

HA5 TM Rejuvenating Hydrator addresses the loss of HA in the skin. Its combination of 5 HAs works immediately to smooth the skin and provide hydration throughout the day on the outer most layers of the skin. In addition, HA5 TM supports the skin's own ability to retain hydration with VITISENSCE® proprietary technology, a potent or "top" blend of antioxidants and peptides.

TNS Essential Serum® addresses skin rejuvenation in the deeper layers of the skin to improve the appearance of skin. Both products include powerful antioxidants, but the blends are very different and are designed to work in different ways to support the skin. We recommend people use HA5 TM Rejuvenating Hydrator with TNS Essential Serum® in their skin care regimen.

Dry vs. Dehydrated Skin

Dry skin is a skin type, while dehydration is a skin condition. In both, the skin undergoes transepidermal water loss, or evaporation of water from inside the body. With this water loss, the enzymes that normally help the skin shed cells cannot function properly, resulting in a buildup of cells that makes the skin look rough and dry, contributing to the appearance of fine lines and wrinkles.

Dry skin can be genetic or a symptom of systemic disease. It is caused either by the inadequate production of oil, called sebum, or by an imbalance of fatty acids, ceramide, and cholesterol in the stratum corneum, the barrier layer of the skin. Age is also a factor in dry skin. As we get older, we experience a decline in a main hormone that triggers sebum production.

Dehydrated skin still produces sebum but is temporarily dry because of various factors, including environmental effects such as a dry climate or use of harsh detergents or products on the skin. It is caused by a temporary imbalance of fatty acids and ceramides in the skin's barrier layer, resulting in a temporary spike in transepidermal water loss.

Physician Feedback

"Many patients are surprised to learn there's a difference between moisturization and hydration—moisturization is the process of skin feeling hydrated, while hydration increases the water level in skin, and it's the addition of water that helps to combat signs of aging. The combination of the instant and long-term benefits sets SkinMedica® HA5 TM Rejuvenating Hydrator apart from other HA products on the market, as it's rare to find a topical skin care treatment that delivers immediate smoothing results that patients can see, as well as support skin health for enhanced results overtime."

—Dermatologist, Dr. Sabrina Fabi

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